Phantom Blade Zero Best Medicines Tier List for Every Build

The best medicines in Phantom Blade Zero are Kuye Dew, Phantom Brew, Lament Draught, and Merciful Dew, which make up the S tier of the medicine tier list. Kuye Dew cuts incoming damage, Phantom Brew makes the player untouchable for a few seconds, Lament Draught raises damage output, and Merciful Dew heals big across six uses.

Phantom Blade Zero builds its fights around fast blade work, Sha-Chi combos, and Phantom Edges, and its bosses can turn one misread attack into a lost attempt. With only two medicine slots to fill, the pair a player carries decides how much room each fight leaves for mistakes. Every medicine gets a tier placement, max level stats, a world location, and a spot in the strongest pairings for each playstyle.

Phantom Blade Zero Best Medicines Tier List Summary

• All 17 medicines restore HP, and the strength of their secondary effect decides where each one lands in the tier list

• Players carry two medicine slots, and every charge refills after a rest at a bell

• Kuye Dew, Phantom Brew, Lament Draught, and Merciful Dew form the S tier, holding value across almost every fight in the game

• Vessel Restorative offers a single charge per rest but grows into a full heal, making it the go-to emergency slot for boss attempts

• Green Serpent Brew and Ritual Wine rank lower overall but turn into must-carry picks for status-heavy fights or status builds

• Upgrades follow three cost ladders, with full Lv 7 totals of 27,000, 37,800, or 48,600 in upgrade currency

• The Medicine Case accessory adds 20% healing to every medicine slot

• Strong pairings combine one heal-focused slot with one buff-focused slot to cover both survival and damage

How Medicines Work in Phantom Blade Zero

Phantom Blade Zero has 17 medicines in total, counting the Healing Gourd that players hold from the prologue onward. Each one restores HP on use, and nearly every medicine attaches a second effect that ranges from damage reduction to faster Sha-Chi recovery.

Players run two medicine slots at the same time, and resting at a bell refills every charge. Upgrades raise each medicine from Lv 1 to Lv 7, strengthening its effect and usually adding extra uses along the way.

Every medicine follows one of three upgrade cost ladders on the way to Lv 7.

Merciful Dew shares the cheapest ladder with the Healing Gourd, so players can max an S-tier medicine early in a run for a modest cost. The damage buffs on the priciest ladder take longer to complete, and spreading upgrades across too many of them leaves every slot half finished.

Gear also changes how much each medicine heals. The Medicine Case raises healing from medicines by 20%, and the bonus applies to both slots, so heal-heavy picks scale even further. The list of best accessories covers where to find it alongside other survival gear.

Phantom Blade Zero Best Medicines Tier List

Each tier reflects how often a medicine earns a slot across a full playthrough. Medicines with a strong secondary effect and plenty of uses rank highest, and single-purpose picks drop lower even when they dominate one specific fight.

Here is how every Phantom Blade Zero medicine ranks.

Tier	Images	Medicine	Best Used For
S		Kuye Dew	Hard-hitting bosses
S		Phantom Brew	Escaping lethal attacks
S		Lament Draught	Aggressive damage builds
S		Merciful Dew	Long fights and steady healing
A		Vessel Restorative	Emergency full heals
A		Longevity Tonic	Full heals plus damage at full HP
A		Green Serpent Brew	Status and elemental bosses
A		Spirit-Returning Broth	Guard Break pressure
A		Healing Gourd	Default healing in any build
B		Focus Pill	Sha-Chi heavy combos
B		Simmering Brew	Passive Sha-Chi builds
B		Miracle Remedy	Low HP comebacks
B		Ritual Wine	Status buildup builds
B		Forbidden Concoction	Phantom Edge builds
B		Sha-Chi Blood Catalyst	Heavy Attack combo damage
C		Phantom Remedy	Mixed HP and Sha-Chi recovery
C		Everflow	Long fights against many enemies

Rankings assume each medicine sits at or near Lv 7, since several picks only reach full value after a few upgrades. A medicine sitting at Lv 1 in a high tier can still lose out to a fully maxed pick from a lower one.

Situational picks such as Green Serpent Brew rank below the S tier for general use, yet they swing certain boss fights harder than any all-rounder. Swapping them in before a known status-heavy boss beats carrying them through every area.

S-Tier Medicines in Phantom Blade Zero

S-tier medicines pair solid healing with an effect that stays useful in almost every encounter. Players who lock in any two of them rarely need to rethink their loadout outside of niche boss fights.

Each pick below lists its Lv 1 and Lv 7 values plus the spot where it sits in the world.

• Kuye Dew offers the only damage reduction among all medicines: At Lv 1, a drink cuts incoming damage by 20% for 15 seconds and heals 40% HP over 10 seconds. Lv 7 doubles the reduction to 40% for 25 seconds and raises healing to 60% HP. Players find it in a chest near the Outlaw Trap bell in the Crimson Forest.

• Phantom Brew turns a heal into an escape button: Drinking it restores 50% HP and grants 1 second of Intangible at Lv 1, and no attack can land during that window. Lv 7 stretches the effect to 3 seconds with 70% HP restored across four uses. The medicine waits in a chest near the Whiteshadow's Fall bell at Meigu Lake.

• Lament Draught gives the longest general damage buff among medicines: Lv 1 adds 10% damage for 30 seconds with a 20% HP heal. At Lv 7, the buff climbs to 20% damage for 40 seconds and healing rises to 40% HP. A chest near the Training Grounds Depths bell in the Mandate Encampment holds it.

• Merciful Dew ties for the most uses of any medicine: Lv 1 restores 60% HP over 10 seconds. Lv 7 pushes healing to 80% HP across six uses and adds 150% natural Sha-Chi recovery for 10 seconds. Players pick it up near the Pond of Fading Song bell in Pangzhen.

Kuye Dew and Merciful Dew both heal over time, so drinking either one at very low HP leaves a gap where one stray hit still ends the attempt. Phantom Brew and Lament Draught restore their HP straight away, which makes them the safer press when the health bar is nearly empty.

Lament Draught and Kuye Dew reward drinking at the start of a boss phase, since their buffs last far longer than the heal itself. Saving either one for a low HP moment throws away most of the buff window.

A-Tier Phantom Blade Zero Medicines for Specific Needs

A-tier medicines either deliver huge single heals or solve one problem better than anything else. Most players rotate them into the second slot depending on the boss waiting ahead.

Each A-tier pick below covers a gap the S tier leaves open.

• Vessel Restorative packs the largest heal into a single charge: Lv 1 restores 70% HP and adds 50% natural Sha-Chi recovery for 5 seconds. The heal reaches a full HP refill at Lv 6, and Lv 7 raises the Sha-Chi bonus to 200% for 10 seconds. The medicine keeps only one use at every level, and players find it in a chest near the Valley Sha-Chi Tower 1st Floor bell in Weeping Creek Valley.

• Longevity Tonic restores all HP from the very first level: Lv 7 adds a 20% damage buff for 20 seconds that lasts as long as HP stays full, with three uses per rest. Players collect it near the Meigu Village East Dock bell at Meigu Lake.

• Green Serpent Brew clears every active status effect on use: Lv 1 adds 75% status resistance for 15 seconds and heals 20% HP over time. Lv 7 lifts resistance to 80% for 25 seconds and healing to 40% HP. The medicine sits near the Green Serpent House bell in Pangzhen.

• Spirit-Returning Broth speeds up breaking an enemy guard: Lv 1 adds 10% Guard Break for 30 seconds with a 20% HP heal. At Lv 7, the buff reaches 15% Guard Break for 40 seconds and healing hits 40% HP. Players grab it near the Well of the Three Puppets bell in the Village of Lu.

• Healing Gourd stays dependable in every build from the prologue onward: At Lv 1, the gourd restores 40% HP per drink. Lv 7 raises that to 50% HP across four uses, with an extra 15% healing below 20% HP.

Vessel Restorative and Longevity Tonic fill the same emergency role, so carrying both wastes a slot that a buff medicine could use. Picking one and pairing it with an S-tier buff covers both survival and damage.

Green Serpent Brew does very little against bosses that never apply status effects. Green Serpent Brew's A-tier spot comes from how hard some of the toughest elemental bosses punish players who show up without a cure.

B and C Tier Medicines in Phantom Blade Zero

B and C tier medicines lean on narrow builds or conditions that rarely line up in a normal fight. Each one still earns a slot inside the right setup, and a few outperform the S tier for specific weapons or Phantom Edges.

Here is what each lower-tier medicine does and where players find it.

• Focus Pill cuts Sha-Chi costs from early in the game: Lv 1 lowers Sha-Chi use by 30% for 15 seconds and heals 30% HP over time. Lv 7 pushes the cut to 40% for 20 seconds with 50% HP healing. Players find it in a chest near The Axemaster's Holding Cell bell in Weeping Creek Valley.

• Simmering Brew builds Sha-Chi passively for a set window: Lv 1 fills Sha-Chi over 15 seconds and heals 30% HP over time. Lv 7 extends the window to 25 seconds with 100% faster Sha-Chi recovery and 50% HP healing. The medicine sits near the Pangzhen Bridge Overlook bell in the Crimson Forest.

• Miracle Remedy rewards drinking at low health: Lv 1 heals 30% HP, plus an extra 30% below 35% HP. Lv 7 raises both values to 50% across five uses. A chest near the Crimson Forest Sha-Chi Tower 6th Floor bell holds it.

• Ritual Wine speeds up elemental status buildup: Lv 1 adds 50% Burn, Paralysis, Freeze, and Bleed buildup for 15 seconds with a 20% HP heal. Lv 7 lifts the bonus to 70% for 25 seconds and healing to 40% HP. Players collect it near the Training Grounds bell in the Mirage Estate.

• Forbidden Concoction buffs Phantom Edge damage and nothing else: Lv 1 adds 10% Phantom Edge damage for 15 seconds with a 20% HP heal. Lv 7 doubles the buff to 20% with 40% HP healing across three uses. Players break an object near the Black Serpent House bell in the Village of Lu to get it, and the list of best Phantom Edges shows which skills pair best with it.

• Sha-Chi Blood Catalyst trades safety for combo damage: Lv 1 adds 20% damage to Heavy Attack Sha-Chi Combos for 15 seconds with a 20% HP heal. Lv 7 raises the bonus to 40% for 25 seconds, but the medicine sets the player on fire at every level. Players find it near the Zhang's Hideout bell in Meigu Village.

• Phantom Remedy restores HP and Sha-Chi together over 6 seconds: Lv 1 returns roughly 60% of each, and Lv 7 returns roughly 80% of each across six uses. Taking a hit stops the recovery partway through, which drags the medicine into the C tier. Players pick it up near the Battlefield Ruins bell in the Mandate Encampment.

• Everflow refills itself through enemy kills in long fights: Lv 1 heals 20% HP, and defeating an enemy restores one use once the medicine runs dry. Lv 7 raises healing to 30% HP and adds 25% Sha-Chi Combo damage for 5 seconds after each refill. The medicine sits near the Well of Wei Sanchuan bell in Pangzhen.

Most medicines in the lower tiers heal only 20% to 30% HP at Lv 1, so players should treat them as buffs first and heals second. Pairing one with a strong healer such as Merciful Dew keeps the build alive and still lets the buff do its job.

Everflow and Phantom Remedy fall to the C tier for opposite reasons. Everflow needs a steady supply of enemies that bosses never provide, and Phantom Remedy breaks under the exact pressure where healing matters most.

Best Phantom Blade Zero Medicine Pairings by Playstyle

The two-slot limit means the pair matters more than any single pick. Strong pairings cover both survival and damage, so a missed dodge does not leave the build without an answer.

Each pairing below suits one of the most common playstyles.

• Hard-hitting bosses call for Kuye Dew with Vessel Restorative: Kuye Dew softens every incoming hit during a damage phase, and Vessel Restorative saves a run in one press when HP drops into danger.

• Aggressive damage runs stack Lament Draught with Spirit-Returning Broth: The damage buff and the Guard Break buff overlap for long stretches, letting players break guards faster and punish harder with the best weapons.

• Status-heavy bosses need Green Serpent Brew next to Kuye Dew: Green Serpent Brew clears and resists ailments, and Kuye Dew trims the raw damage that still lands through the status pressure.

• Sha-Chi combo builds run Focus Pill with Simmering Brew: One cuts the cost of every Sha-Chi move, and the other refills the bar, so combo chains last far longer between resets.

Players can rotate the buff slot freely between fights and keep the heal slot fixed. A dependable heal in one slot lets the second slot change with every boss without leaving the build exposed.

Testing a pairing against story bosses first gives players a feel for each buff window. The same practice pays off in the optional fights covered in the secret boss locations list, where one misjudged buff can cost a full attempt.

FAQs About Phantom Blade Zero Best Medicines

Final Words

Medicine choice in Phantom Blade Zero grows more important as difficulty climbs. On Hellwalker difficulty, the damage reduction from Kuye Dew carries far more weight, since incoming hits leave much less room for a slow heal to catch up.

The smartest long-term plan treats one slot as permanent and the other as a boss-specific tool. Players who sink upgrades into a single S-tier heal early, then build up one or two situational picks, end up with a loadout that adapts to every fight without spreading their upgrade budget across medicines they rarely touch.

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